Central West End Vacations from $197

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to $2,000 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Your Central West End Vacation

Whatever your style of travel, you can see and do more with a tailor-made Central West End vacation package. Spend your break enjoying this neighborhood's shopping and its other charms. When it's time to head out and explore, you'll find lots of big-name attractions nearby including St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis. Visit one, two or more during your trip to Central West End. Stop daydreaming and start doing. When it's time to lock in your vacation to Central West End, Expedia will help get you there.

The Latest Central West End Vacation Packages

Price found within the past 48 hours. Click for updated prices.
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Riverport
Save 100% on your flight
$197
per person
Nov 6 - Nov 9
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
7.6/10 Good! (1,012 reviews)
Breakfast was a laugh. Toast and microwave oatmeal, lol. At least there was coffee.

Reviewed on Sep 22, 2026

The Wildwood Hotel

The Wildwood Hotel

$402
per person
Nov 6 - Nov 9
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.2/10 Wonderful! (1,657 reviews)
Very nice hotel. Only concern is the single elevator, since the front desk is on a different level than the bulk of the rooms. Makes for congestion in the morning when housecleaning staff are using it.

Reviewed on Sep 23, 2026

Residence Inn by Marriott St. Louis West County

Residence Inn by Marriott St. Louis West County

$529
per person
Nov 4 - Nov 9
found 1 day ago
Roundtrip non-stop flight included
Philadelphia (PHL) to St. Louis (STL)
9.2/10 Wonderful! (266 reviews)
Ive stayed here before. Rooms are nice because they have a desk kitchen snd couch. Bed was not good. We stayed here because our ac went out. I called and confirmed pet friendly booked and paid for the room only to arrive and be told its $100 pet fee. Thats not fair or ok.

Reviewed on Sep 4, 2026

The Cheshire

The Cheshire

Save 100% on your flight
$387
per person
Nov 6 - Nov 9
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
8.8/10 Excellent! (1,004 reviews)
The Knight Center at Washington University

The Knight Center at Washington University

Save 100% on your flight
$310
per person
Nov 6 - Nov 9
found 1 day ago
Roundtrip flight included
Atlanta (ATL) to St. Louis (STL)
9.4/10 Exceptional! (668 reviews)
Very nice. Excellent location

Reviewed on Sep 22, 2026

Where to stay in Central West End

Find the best Central West End areas and neighborhoods for the activities you enjoy most. Learn more about Central West End
A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

4 out of top 10 points of interest in this area

Head to the heart of the largest city in Missouri for its cultural hotspots, nightlife and a colossal monument that towers over the Mississippi River.

The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

An ornate hall with arched ceilings and intricate patterns.

Downtown West

2 out of top 10 points of interest in this area

If you're spending some time in Downtown West, St. Louis Union Station and Enterprise Center are top sights worth seeing.

Central West End Hotel Deals

The West End

The West End

4215 Lindell Blvd St. Louis MO
Fully refundableReserve now, pay when you stay
$96 nightly
$108 total
Sep 27 - Sep 28
Total with taxes and fees
8.6/10 Excellent! (650 reviews)
"Great for a one night stay"

Reviewed on Sep 22, 2026

The West End
 The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis

212 N Kingshighway St. Louis MO
$174 nightly
$205 total
Oct 4 - Oct 5
Total with taxes and fees
9.2/10 Wonderful! (1,009 reviews)
"Loved the location and everything about this place. Will definitely stay again"

Reviewed on Sep 23, 2026

The Royal Sonesta Chase Park Plaza St. Louis
Aloft by Marriott St Louis Central West End

Aloft by Marriott St Louis Central West End

4245 Duncan Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
$114 nightly
$133 total
Sep 27 - Sep 28
Total with taxes and fees
Aloft by Marriott St Louis Central West End
See all 2,007 properties in Central West End
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Central West End attractions

A grand cathedral interior with intricate mosaics, a large central altar, and a circular stained glass window.

Cathedral Basilica of St. Louis

8.6/10 (557 reviews)
Marvel at the vast collection of mosaic art that beautifies the interior of this colossal cathedral built in the Romanesque Revival style.
See properties
A chessboard with black and white pieces in a castle-themed setting.

World Chess Hall of Fame

8.2/10 (11 reviews)
Play a game of chess on a giant outdoor board, inspect chess-related artifacts and view artworks inspired by the two-player board game at this fascinating center.
See properties

Blue Strawberry

You can make plans for a show at Blue Strawberry during your trip to St. Louis. Discover the area's top-notch restaurants and its acclaimed theater scene.
See properties

Things to do

The Gateway Arch National Park & Museum

StL's Signature "Sights and Bites" - Private Tour in St. Louis

$175
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

$24
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
Self Guided Walking & Driving Audio Tour St. Louis

Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP

$15
per traveler
Self Guided Walk & Drive Audio Tour St. Louis & Gateway Arch NP
See all activities in St. Louis

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.